The Allen Discovery Center for Neuroimmune Interactions (ADCNI) aims to transform the field of peripheral neuroimmunology through scientific advances at the conceptual, technological, and programmatic level. Our team of renowned scientists have revolutionized our understanding of how the immune and nervous systems communicate. Collectively, our work shows that immune cells can act as environmental and internal sensors to influence mammalian behavior (e.g., itch, breathing, etc.), and that the sensory nervous system itself can act as an immune organ. Our work redefines the understanding of biology and reveals new therapeutic avenues. The ADCNI envisions a future in which asthma is treated by stimulating nerves in the skin, the source of anxiety is as much in the gut as it is in the brain, and treating pain in cancer is a form of chemotherapy. Thus, the vision of ADCNI is to revolutionize our understanding of basic biological systems and advance an entirely new therapeutic paradigm in medicine.